Differentiation of ectoderm implanted into the primordium of the limb bud in the amphibian embryo and its influence upon the limb.
نویسنده
چکیده
It was shown by Brandt (1944) that phocomelias and atrophied limbs can be produced experimentally after deep implantation of embryonic ectoderm into the primordium of the limb bud in the tail-bud stage (Harrison's stage no. 35) of the amblystoma embryo. The following microscopical analysis of the operated specimens shows some new results which concern the histological changes of the implanted embryonic ectoderm within the tissues of the host embryo and their effect on the limb primordium.
منابع مشابه
In Vitro Study of the Protective Effects of Hydroalcholic Extract of Soybean against Impact of Oxidative Damage on Osteogenesis and Chondrogenesis of Mouse Limb Bud
Introduction: Oxidative stress has been implicated in the pathogenesis of various diseases affecting chondrogenesis or the function of articular cartilage. The purpose of the present study was to find the effect of soybean extract on reduction of detoriation effects of oxidativestress in embryonic chondrogenesis in vitro. Methods: In order to separate ectoderm from mesenchyme, the limb buds ...
متن کاملاثرات مورفوژنیک و تراتوژنیک اسید رتینوئیک در جنین جوجه
ABSTRACT: Retinoic acid "one of the derivatives of vitamin A "has different morphogenic and teratogenic effects on developing organs. For this reason, the present study is an attempt to examine the effects of retinoic acid on limb bud ,eye and body axis of chick embryo in the stages of 11-12 Humburger and Hamilton. The experiments cartied out in this study was based on 140 white eggs which h...
متن کاملThe limb deformity gene is required for apical ectodermal ridge differentiation and anteroposterior limb pattern formation.
To gain insight into the role of the limb deformity (ld) gene in limb morphogenesis, we examined the morphologic details of early embryonic limb formation in the mutant ld/ld mouse. Initial morphological differences between wild-type and homozygous ld embryos are apparent during early gestational day 10, a time period during which anteroposterior limb morphogenesis occurs. As a result of a shor...
متن کاملCyclosporine Effects on Chick Limb Bud Mesenchyme and DNA Content
Background: Cyclosporine A (CsA) is a powerful immunosuppressive agent, which is used for the prevention of allograft rejection and for the treatment of autoimmune diseases. Many transplant recipients must take this medicine for the rest of their lives. Females in reproductive age group on prolonged CsA therapy have legitimate concerns about drug effects on pregnancy. Objective: To explore Cs...
متن کاملEctoderm and mesoderm interactions in the limb bud of the chick embryo studied by transfilter cultures: cartilage differentiation and ultrastructural observations.
The wing mesoderm of the chick embryo cultured in vitro without ectoderm is able to differentiate into cartilage from stage 17 (Hamburger & Hamilton, 1951). But before this stage the presence of ectoderm is necessary. In transfilter cultures of wing-bud ectoderm and mesoderm, the mesodermal response as measured by chondrogenesis was directly related to the pore size (0.2--1 micrometer) of the f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of experimental biology
دوره 22 شماره
صفحات -
تاریخ انتشار 1946